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    SMAD3

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  • 价格
    ¥899.00
  • 应用
    WB
    IHC
  • 特异性
    大鼠
    小鼠
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    100%
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  • 产品概述

    Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Smad1 and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 and Smad3 are involved in TGF-β and Activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities through interaction with various Smad family members. The phosphorylated receptor-regulated Smad issociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses.


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